Chemicals and textiles are deeply interwoven. Textiles go through numerous production steps from the raw material to the finished product. For example, the cotton used to produce one t-shirt is estimated to require one-third of a pound of toxic chemicals. Both synthetic and natural fibers require a large amount of chemical processing throughout the garment manufacturing process as well as through the life cycle of a garment. This includes establishing garment performance and function, such as water resistance and stretch, as well as design, including coloring, dying and printing. Twenty years ago, most companies didn’t have any idea of what was in their products unless there was a legal requirement. Although chemicals remain largely invisible and unnoticed in the final product, many chemicals pose a risk to the health of the employees who work in close proximity to the chemicals, the consumers who wear the garments on or near their skin, and the environment. The environment is especially at risk because chemicals are an integral part of millions of manufacturing processes throughout a supply chain, increasing the risk of chemical release through air, vapor, or wastewater, all of which enters the ecosystem. The number of suppliers involved throughout the supply chain has rapidly increased in the past 20 years. For brands, this has resulted in a complex, interlocked system with a low degree of oversight and control. Chemical compositions to improve garment performance and functionality, or to replace a chemical determined to be hazardous, are developing rapidly. Brands struggle to maintain abreast to the continuously updating legislation and regulation, aimed at consumer safety. Incorporating chemical change management throughout the textile supply chain is a primary driver to establish responsible and safe chemical management. Chemical management is important in order to understand what is being put into the supply chain stream. A primary part of effectively managing and producing safe apparel is being able to prevent harmful chemicals from entering the process stream right from the start.